A research team led by Prof. Ding BaoQuan from the National Center for Nanoscience and Technology (NCNST) proposed a strategy to engineer versatile DNA nanodevices for intelligent cancer treatment. This study was published in “Angew. Chem. Int. Ed.”. Article link: https://www.onlinelibrary.wiley.com/doi/10.1002/anie.202009842 .
In this study, researchers constructed a DNA nanodevice functionalized with small interference RNA (siRNA) within its inner cavity and the chemotherapeutic drug doxorubicin (DOX) intercalated in the DNA duplexes. The incorporation of disulfide bonds allows the triggered mechanical opening and release of siRNA in response to intracellular glutathione (GSH) in tumors to knockdown genes key to cancer progression. Combining RNA interference and chemotherapy, the nanodevice induced potent cytotoxicity and tumor growth inhibition, without observable systematic toxicity. Given its autonomous behavior, exceptional designability, potent antitumor activity and marked biocompatibility, this DNA nanodevice represents a promising strategy for precise drug design for cancer therapy.
This work is supported by the National Natural Science Foundation of China, the National Basic Research Program of China, Beijing Municipal Science & Technology Commission, Key Research Program of Frontier Sciences, CAS, the Strategic Priority Research Program of CAS, Interdisciplinary Innovation Team and K. C. Wong Education Foundation.
Figure. Design of a multifunctional tubular DNA nanodevice