Yuliang Zhao

2018.10-now Director-General, National Center for Nanoscience and Technology of China 

2011-2018  Deputy Director-General, National Center for Nanoscience and Technology of China

2008- now  Director, Chinese Academy of Sciences Key Lab for Biomedical Effects of Nanomaterials and Nanosafety

2005-2008  Executive Dean, College of Chemistry, Graduate University of Chinese Academy of Sciences (previously GUCAS)

2001-now   Professor, Institute of High Energy Physics, Chinese Academy of Sciences

1999-2001  JSPS Fellow, Tokyo Metropolitan University & RIKEN, Tokyo, Japan

1996-1999  PhD in Chemistry, Tokyo Metropolitan University, Tokyo, Japan

1993-1996  M.D in Chemistry, Tokyo Metropolitan University, Tokyo, Japan

1981-1985  MSc in Chemistry, Sichuan University, China

A. Ten representative publications in Nanotoxicology
(Note: Prof. Zhao is corresponding author) 

1. Haifang Wang, Jing Wang, Xiaoyong Deng, Hongfang Sun, Zujin Shi, Zhennan Gu, Yuanfang Liu, Yuliang Zhao, Biodistribution of carbon single-wall carbon nanotubes in mice, Journal of Nanoscience and Nanotechnology, 4, 1019-1024 (2004).   

Note: the work was the one of very few nanotoxicity studies of engineered nanomaterials in the earliest time. After then, the nanotoxicology research on engineered nanomaterials of his team was ranked as the world Top 25 Hottest Papers in fields of “Pharmacology + Toxicology + Pharmacy” for 30 seasons in 2005-2015.  

2. Guang Jia , Haifang Wang, Lei Yan, Xiang Wang, Rongjuan Pei, Tao Yan, Yuliang Zhao, Xinbiao Guo, Cytotoxicity of carbon nanomaterials: single-wall nanotube, multi-wall nanotube, and fullerene, Environmental Science & Technology, 39, 1378-1383 (2005). 

Note: the work has been cited 1559 times by May 2020, and was remarked by UCLA scientist as “The first highly cited nano-paper concerned cytotoxicity“. The nanotoxicology research on engineered nanomaterials of his team was ranked as the world Top 25 Hottest Papers in fields of “Pharmacology + Toxicology + Pharmacy” for 30 seasons in 2005-2015. 

3. Zhen Chen, Huan Meng, Genmei Xing, Chunying Chen, Yuliang Zhao, Guang Jia, Tiancheng Wang, Hui Yuan, Chang Ye, Feng Zhao, Zhifang Chai, Chaofeng Zhu, Xiaofeng Fang, Baocheng Ma, Lijun Wan, Acute toxicological effects of copper nanoparticles in vivo, Toxicology Letters, 163, 109-120 (2006). 

Note: the work has been cited >960 times by May 2020. The nanotoxicology research on engineered nanomaterials of his team was ranked as the world Top 25 Hottest Papers in fields of “Pharmacology + Toxicology + Pharmacy” for 30 seasons in 2005-2015. 

4. Huan Meng, Zhen Chen, Geng Mei Xing, Hui Yuan, Chunying Chen, Feng Zhao, Chengcheng Zhang, Yuliang Zhao, Ultrahigh reactivity provokes nanotoxicity: Explanation of oral toxicity of nano-copper particles, Toxicology Letters, 175, 102-110 (2007). 

Note: the work has been cited >240 times by May 2020. The nanotoxicology research on engineered nanomaterials of his team was ranked as the world Top 25 Hottest Papers in fields of “Pharmacology + Toxicology + Pharmacy” for 30 seasons in 2005-2015. 

5. Jiangxue Wang, Ying Liu, Fang Jiao, Fang Lao, Wei Li, Yiqun Gu, Yufeng Li, Cuicui Ge, Guoqiang Zhou, Bai Li, Yuliang Zhao, Zhifang Chai, Chunying Chen, Time-dependent translocation and potential impairment on central nervous system by intranasally instilled TiO2 nanoparticles, Toxicology, 254, 82-90 (2008).  

Note: the work has been cited >400 times by May 2020. The nanotoxicology research on engineered nanomaterials of his team was ranked as the world Top 25 Hottest Papers in fields of “Pharmacology + Toxicology + Pharmacy” for 30 seasons in 2005-2015. 

6. Cuicui Ge, Fang Lao, Wei Li, Yufeng Li, Chunying Chen, Xueying Mao, Bai Li, Zhifang Chai, Yuliang Zhao, Quantitative analysis of metal impurities in carbon nanotubes: efficacy of different pretreatment protocols for ICPMS spectroscopy, Analytical Chemistry, 80, 9426-9434 (2008).

Note: the work has been cited > 150 times by May 2020. The nanotoxicology research on engineered nanomaterias of his team was ranked as the world Top 25 Hottest Papers in fields of “Pharmacology + Toxicology + Pharmacy” for 30 seasons in 2005-2015. 

7. Zhen Chen, Huan Meng, Gengmei Xing, Hui Yuan, Feng Zhao, Tiancheng Wang, Guang Jia, Chang Ye, Zhifang Chai, Yuliang Zhao, Age-related differences in pulmonary and cardiovascular responses to SiO2 nanoparticle inhalation: nanotoxicity has susceptible population, Environmental Science & Technology, 42, 8985-8992 (2008). 

Note: the work has been cited > 130 times by May 2020. The nanotoxicology research on engineered nanomaterials of his team was ranked as the world Top 25 Hottest Papers in fields of “Pharmacology + Toxicology + Pharmacy” for 30 seasons in 2005-2015.

8. Cuicui Ge, Jiangfeng Du, Lina Zhao, Liming Wang, Ying Liu, Denghua Li, Yanlian Yang, Ruhong Zhou, Yuliang Zhao, Zhifang Chai, Chunying Chen, Binding of blood proteins to carbon nanotubes reduces cytotoxicity, PNAS (Proceedings of the National Academy of Sciences of the United States of America), 108, 16968-16973 (2011). 

Note: the work has been cited >720 times by May 2020. The nanotoxicology research on engineered nanomaterials of his team was ranked as the world Top 25 Hottest Papers in fields of “Pharmacology + Toxicology + Pharmacy” for 30 seasons in 2005-2015.  

9. Feng Zhao, Ying Zhao, Ying Liu, Xueling Chang, Chunying Chen, Yuliang Zhao, Cellular uptake, intracellular trafficking, and cytotoxicity of nanomaterials, Small, 7, 1322-1337 (2011). 

Note: the work has been cited >830 times by May 2020. The nanotoxicology research on engineered nanomaterials of his team was ranked as the world Top 25 Hottest Papers in fields of “Pharmacology + Toxicology + Pharmacy” for 30 seasons in 2005-2015. 

10. Motao Zhu, Guangjun Nie, Huan Meng, Tian Xia, Andre Nel, Yuliang Zhao, Physicochemical properties determine nanomaterial cellular uptake, transport, and fate, Accounts of Chemical Research, 46, 622-631 (2013).
Note: the work has been cited >460 times by May 2020. The nanotoxicology research on engineered nanomaterials of his team was ranked as the world Top 25 Hottest Papers in fields of “Pharmacology + Toxicology + Pharmacy” for 30 seasons in 2005-2015. 

B. Ten representative publications in Nanomedicine
(Note: Prof. Zhao is corresponding author) 

1. Chunying Chen, Gengmei Xing, Jiangxue Wang, Yuliang Zhao, Bai Li, Jun Tang, Guang Jia, Tiancheng Wang, Jin Sun, Li Xing, Hui Yuan, Yuxi Gao, Huan Meng, Zhen Chen, Feng Zhao, Zhifang Chai, Xiaohong Fang, Multihydroxylated [Gd@C82(OH)22]n nanoparticles: antineoplastic activity of high efficiency and low toxicity, Nano Letters, 5, 2050-2057 (2005). 

Note: the work directly uses manufactured nanomaterials [Gd@C82(OH)22]n as novel cancer medicine but not as usual as the drug carrier, has been cited >320 times by May 2020, and was commented:"...... may lead to a revolutionary shift in the strategy applied for cancer management by directly using a multifunctional nanoscale particulate itself as a new form of medicine."; "...... may open new avenues in human cancer therapeutics".  

2. Xueyun Gao, Gengmei Xing, Yanlian Yang, Xiaoli Shi, Ru Liu, Weiguo Chu, Long Jing, Feng Zhao, Chang Ye, Hui Yuan, Xiaohong Fang, Chen Wang, Yuliang Zhao, Detection of trace Hg2+ via induced circular dichroism of DNA wrapped around single-walled carbon nanotubes, JACS (Journal of the American Chemical Society), 130, 9190-9191 (2008). 

Note: the work has been cited >120 times by May 2020.

3. Xing-Jie Liang, Huan Meng, Yingze Wang, Haiyong He, Jie Meng, Juan Lu, Paul C. Wang, Yuliang Zhao, Xueyun Gao, Baoyun Sun, Chunying Chen, Genmei Xing, Dingwu Shen, Michael M. Gottesman, Yan Wu, Jun-jie Yin, Lee Jia, Metallofullerene nanoparticles circumvent tumor resistance to cisplatin by reactivating endocytosis, PNAS (Proceedings of the National Academy of Sciences of the United States of America), 107, 7449-7454 (2010).  

Note: the work directly uses manufactured nanomaterials [Gd@C82(OH)22]n as novel cancer medicine but not as usual as the drug carrier, has been cited >230 times by May 2020, and was commented :"...... may lead to a revolutionary shift in the strategy applied for cancer management by directly using a multifunctional nanoscale particulate itself as a new form of medicine."; "...... may open new avenues in human cancer therapeutics".

4. Cuiji Sun, Hui Yang, Yi Yuan, Xin Tian, Liming Wang, Yi Guo, Li Xu, Jianlin Lei, Ning Gao, Gregory J. Anderson, Xing-Jie Liang, Chunying Chen, Yuliang Zhao, Guangjun Nie, Controlling assembly of paired gold clusters within apoferritin nanoreactor for in vivo kidney targeting and biomedical imaging, JACS (Journal of the American Chemical Society), 133, 8617-8624 (2011).

Note: the work has been cited >220 times by May 2020.  

5. Seung-gu Kang, Guo qiang Zhou, Ping Yang, Ying Liu, Baoyun Sun, Tien Huynh, Huan Meng, Lina Zhao, Gengmei Xing, Chunying Chen, Yuliang Zhao, Ruhong Zhou, Molecular mechanism of pancreatic tumor metastasis inhibition by Gd@C82(OH)22 and its implication for de novo design of Nanomedicine, PNAS (Proceedings of the National Academy of Sciences of the United States of America), 109, 15431-15436 (2012).

Note: the work directly uses manufactured nanomaterials [Gd@C82(OH)22]n as novel cancer medicine but not as usual as the drug carrier, has been cited >170 times by May 2020, and was commented:"...... may lead to a revolutionary shift in the strategy applied for cancer management by directly using a multifunctional nanoscale particulate itself as a new form of medicine."; "...... may open new avenues in human cancer therapeutics".  

6. Gan Tian, Zhanjun Gu, Liangjun Zhou, Wenyan Yin, Xiaoxiao Liu, Liang Yan, Shan Jin, Wenlu Ren, Gengmei Xing, Shoujian Li, and Yuliang Zhao, Mn2+ dopant-controlled synthesis of NaYF4: Yb/Er upconversion nanoparticles for in vivo imaging and drug delivery, Advanced Materials, 24, 1226-1231 (2012).  

Note: the work has been cited >660 times by May 2020.  

7. Ying Liu, Chunying Chen, Pengxu Qian, Xuefei Lu, Baoyun Sun, Xiao Zhang, Liming Wang, Xingfa Gao, Han Li, Zhiyun Chen, Jinglong Tang, Weijie Zhang, Jinquan Dong, Ru Bai, Peter E. Lobie, Qingfa Wu, Suling Liu, Huafeng Zhang, Feng Zhao, Max Wicha, Tao Zhu, Yuliang Zhao, Gd-metallofullerenol nanomaterial as non-toxic breast cancer stem cell-specific inhibitor, Nature Communications, 6, 5988 (2015). 

Note: the work directly uses manufactured nanomaterials [Gd@C82(OH)22]n as novel cancer medicine but not as usual as the drug carrier, has been cited > 110 times by May 2020, and was commented:"-may lead to a revolutionary shift in the strategy applied for cancer management by directly using a multifunctional nanoscale particulate itself as a new form of medicine."; "-may open new avenues in human cancer therapeutics".   

8. Suping Li, Qiao Jiang, Shaoli Liu, Yinlong Zhang, Yanhua Tian, Chen Song, Jing Wang, Yiguo Zou, Gregory J Anderson, Jing-Yan Han, Yung Chang, Yan Liu, Chen Zhang, Liang Chen, Guangbiao Zhou, Guangjun Nie, Hao Yan, Baoquan Ding, Yuliang Zhao, A DNA nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo, Nature Biotechnology, 36, 258-264 (2018).

Note: the work was rated as a “landmark“ and highlighted by more than 100 media worldwide, including Nature Review Cancer, Nature Biotechnology, Science Translational Medicine, etc, and was elected as the “Top Technical Advances”by Scientist Magazine, USA, in December, 2018.

9. Xuexiang Han, Yiye Li, Ying Xu, Xiao Zhao, Yinlong Zhang, Xiao Yang, Yongwei Wang, Ruifang Zhao, Gregory J. Anderson, Yuliang Zhao, Guangjun Nie, Reversal of pancreatic desmoplasia by re-educating stellate cells with a tumour microenvironment activated nanosystem, Nature Communications, 9, 3390 (2018).  

10. Suping Li, Yinlong Zhang, Shih-Hsin, Ho, Bozhao Li, Meifang Wang, Wei Xiong, Na Yang, Guangna Liu, Zefang Lu, Junchao Xu, Quanwei Shi, Jing-Yan Han, Lirong Zhang, Yan Wu, Yuliang Zhao, Guangjun Nie, Co-administration of the chemotherapeutic drug doxorubicin enhances the long-term healing efficacy of tumor infarction therapy, Nature Biomedical Engineering, 3, (2019). 

11. Chang Liu, Bei Liu, Jian Zhao, Zhenghan Di, Daquan Chen, Zhanjun Gu, Lele Li, Yuliang Zhao, Nd³⁺-sensitized upconversion metal-organic frameworks for mitochondria-targeted amplified photodynamic therapy, Angewandte Chemie-International Edition, 59, 2634-2638 (2020).

12. Hong-Wei An, Li-Li Li, Yi Wang, Ziqi Wang, Dayong Hou, Yao-Xin Lin, Sheng-Lin Qiao, Man-Di Wang, Chao Yang, Yong Cong, Yang Ma, Xiao-Xiao Zhao, Qian Cai, Wen-Ting Chen, Chu-Qi Lu, Wanhai Xu, Hao Wang, Yuliang Zhao, A tumour-selective cascade activatable self-detained system for drug delivery and cancer imaging, Nature Communications, 10, 4861 (2020).