National Center for Nanoscience and Technology, China

Faculty

Xingjie LIANG

Title：	Professor
E-mail：	liangxj@nanoctr.cn
Affiliation：	National Center for Nanoscience and Technology (NCNST) No.11 Beiyitiao Zhongguancun, 100190 Beijing, P. R. China
Group Webpage：	http://www.nanoctr.cn/liangxingjie/ketizu/

Education and Professional Experience:

Professor Xing-Jie LIANG got Ph.D at National Key Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences. He finished his postdoc with Dr. Michael M. Gottesman (member of NAS and Deputy Director of NIH, USA) for 5 years at Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. Then, he worked as a Research Fellow at Surgical Neurology Branch, NINDS (National Institute of Neurological Diseases and Strokes, NIH). He was an Assistant professor at School of Medicine, Howard University. Professor Liang currently is deputy director of Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China and a principal investigator at Center for Excellence in Nanoscience, Chinese Academy of Sciences. Professor Liang was granted with "National Distinguished Young Scholar" by NSFC (National Natural Science Foundation of China), and awarded with "Special Government Allowances" by Department of State and many other prizes. Professor Liang is the elected Fellow of American Institute for Medical and Biological Engineering and Faculty Member of F1000 Research (Pharmacology & Drug Delivery). He is also a founder member of International Society of Nanomedicine and current president of Chinese Association of Nanobiology. He is the associated director of nanobiomateirals-related committees and council member of several scientific associations, such as China Society of Biomaterials (CSBM), Chinese Medicinal Biotechnological Association (CMBA), Chinese Pharmaceutical Association (CPA) and Biophysical Society of China (BSC). Professor Liang is current Editor-in-Chief of Current Drug Delivery, Associate Editors of Biomaterialsand Biophysics Report; Advisory editorial board member of ACS Nanoand Advanced Therapeutics; Editorial member of Bioconjugate Chemistry,Theranostics. His research interests are in elucidating mechanisms to improve drugability and nanomedicinal bioavailability by nanotechnology in vitro and in vivo, and novel strategies to increase therapeutic efficiency on cancers and infective diseases. Developing drug delivery strategies for prevention/circumvent of clinical adaptive treatment tolerance (ATT) are current programs ongoing in Professor Liang's lab based on understanding of basic physio-chemical and biological processes of nanomedicine. Prof. Liang has successfully developed "Injectable Nanomicelles Powders with Irinotecan" approved with CFDA and transfered NDA to pharmaceutical industry for clinical trials with China Resources Pharmaceutical Group.

Research Interests:

Research Interests

Design, synthesis, structural optimization, and functional characterization of nanodrugs, along with their biological mechanisms in clinical applications.

Selected Publications (full list via Google Scholar)

1. Qing G. et al. Liang X.-J.* Thermo-responsive triple-function nanotransporter for efficient chemo-1 photothermal therapy of multidrug-resistant bacterial infection. Nature Communications. 2019. 10(1):4336.

2. Huo S. et al. Liang X.-J.* Gold-DNA NanoSunflowers for Efficient Gene Silencing with Controllable Transformation. Science Advances. 2019. 5(10):eaaw6264.

3. Ma X. et al. Liang X.-J.* Evaluation of Turning-Sized Gold Nanoparticle (TSGN) on Cellular Adhesion by Golgi disruption in vitro and in vivo. Nano Letter. 2019. 19(12):8476-8487.

4. Gong N. et al. Liang X.-J.* Carbon dot-supported atomically-dispersed gold (CAT-g) as a mitochondrial oxidative stress amplifier for cancer treatment. Nature Nanotechnology. 2019. 14. 379-387.

5. Zhang T, et al. Liang XJ* Fluorinated Oligoethylenimine Nanoassemblies for Efficient siRNA-Mediated Gene Silencing in Serum-Containing Media by Effective Endosomal Escape. Nano Letter. 2018. 18(10):6301-6311.

6. Zhao Y, et al. Liang XJ*. Spatiotemporally Controllable Peptide-based Nanoassembly in Single Living Cells for a Biological Self-portrait. Advanced Materials 2017. 29,1601128.

7. Xue, X.; et al. Liang, X. J*. Aggregated single-walled carbon nanotubes attenuate the behavioural and neurochemical effects of methamphetamine in mice. Nature Nanotechnology 2016, 11 (7), 613-620.

8. Wei, T.; et al. Liang, X.J*. Anticancer drug nanomicelles formed by self-assembling amphiphilic dendrimer to combat cancer drug resistance. PNAS. (Proc Natl Acad Sci U S A.). 2015. 112 (10): 2978-2983.

9. Xue, X.; et al. Liang, X. J*. Single-walled carbon nanotubes alleviate autophagic/lysosomal defects in primary glia from a mouse model of Alzheimer's disease. Nano Letters 2014, 14 (9), 5110-5117.

10. Xue, X.; et al. Liang, X. J*. Spatiotemporal drug release visualized through a drug delivery system with tunable aggregation-induced emission. Advanced Materials 2014, 26 (5), 712-717.

11. Wei, T.; et al. Liang, X. J.* Functionalized nanoscale micelles improve drug delivery for cancer therapy in vitro and in vivo. Nano Letters 2013, 13 (6), 2528-2534.

12. Huo, SD.; et al. Liang, X. J.* Superior penetration and retention behavior of 50nm gold nanoparticles in tumor. Cancer Research. 2013 73:319-330.

13. Liang, X.J. * et al. Metallofullerene Nanoparticles Circumvent Tumor Resistance to Cisplatin by Reactivating Endocytosis. PNAS. (Proc Natl Acad Sci U S A.). 2010. 107(16):7449-7454.