National Center for Nanoscience and Technology, China

Faculty

Lele LI

Title：	Professor
E-mail：	lilele@nanoctr.cn
Affiliation：	National Center for Nanoscience and Technology (NCNST) No.11 Beiyitiao Zhongguancun, 100190 Beijing, P. R. China
Group Webpage：	http://www.nanoctr-lllab.com/

Education and Professional Experience:

Prof. Lele LI received his Ph.D. from the Peking University in 2010 under the supervision of Prof. Chun-Hua Yan. He was a postdoctoral associate in the laboratory of Prof. Yi Lu at University of Illinois at Urbana- Champaign (UIUC) during 2010-2012, and then worked with Prof. Robert Langer and Prof. Daniel Kohane as a postdoctoral associate at MIT and Harvard Medical School during 2012-2016. He joined the National Center for Nanoscience and Technology as Professor in July 2016.

Research Interests:

Research Interests

Spatiotemporally-controlled biosensing and imaging; Precision diagnosis and therapy

Selected Publications (full list via Researchgate)

1. Y. Shao, B. Liu, Z. Di, G. Zhang, L. Sun, L. Li*. C.-H. Yan. Engineering of Upconverted Metal–Organic Frameworks for Near-Infrared Light-Triggered Combinational Photodynamic/Chemo-/Immunotherapy against Hypoxic Tumors. J. Am. Chem. Soc. 2020, 142 (8), 3939-3946.

2. C. Liu, B. Liu, J. Zhao, Z. Di, D. Chen, Z. Gu, L. Li*, Y. Zhao*. Nd3+-Sensitized Upconversion Metal-Organic Frameworks for Mitochondria-Targeted Amplified Photodynamic Therapy. Angew. Chem., Int. Ed. 2020, 59 (7), 2634-2638.

3. H. Chu, J. Zhao, Y. Mi, Z. Di, L. Li*. NIR-Light-Mediated Spatially Selective Triggering of Anti-Tumor Immunity via Upconversion Nanoparticle-Based Immunodevices. Nat. Commun. 2019, 10, 2839.

4. J. Zhao, H. Chu, Y. Zhao, Y. Lu, L. Li*. A NIR Light-Gated DNA Nanodevice for Spatiotemporally Controlled Imaging of MicroRNA in Cells and Animals. J. Am. Chem. Soc. 2019, 141 (17), 7056-7062.

5. H. Chu, J. Zhao, Y. Mi, Y. Zhao, L. Li*. Near-infrared Light-Initiated Hybridization Chain Reaction for Spatially and Temporally Resolved Signal Amplification. Angew. Chem., Int. Ed. 2019, 58 (42), 14877-14881.

6. B. Liu, F. Hu, J. Zhang, C. Wang, L. Li*. A Biomimetic Coordination Nanoplatform for Controlled Encapsulation and Delivery of Drug-Gene Combinations. Angew. Chem., Int. Ed. 2019, 58 (26), 8804-8808.

7. M. Li, C. Wang, Z. Di, H. Li, J. Zhang, W. Xue, M. Zhao, K. Zhang, Y. Zhao, L. Li*. Engineering Multifunctional DNA Hybrid Nanospheres through Coordination-Driven Self-Assembly. Angew. Chem., Int. Ed. 2019, 58 (5), 1350-1354.

8. Z. Di, J. Zhao, H. Chu, W. Xue, Y. Zhao, L. Li*. An Acidic-Microenvironment-Driven DNA Nanomachine Enables Specific ATP Imaging in the Extracellular Milieu of Tumor. Adv. Mater. 2019, 31 (33), 1901885.

9. J. Zhao, J. Gao, W. Xue, Z. Di, H. Xing, Y. Lu, L. Li*. Upconversion Luminescence-Activated DNA Nanodevice for ATP Sensing in Living Cells. J. Am. Chem. Soc. 2018, 140 (2), 578-581.

10. Y. Li, Z. Di, J. Gao, P. Cheng, C. Di, G. Zhang, B. Liu, X. Shi, L.-D. Sun, L. Li*. C.-H. Yan, Heterodimers Made of Upconversion Nanoparticles and Metal-Organic Frameworks. J. Am. Chem. Soc. 2017, 139 (39), 13804-13810.