| Title： | Professor |
| E-mail： | caoyh@nanoctr.cn |
| Affiliation： | National Center for Nanoscience and Technology (NCNST） No.11 Beiyitiao Zhongguancun, 100190 Beijing, P. R. China |
| Group Webpage： | www.yuhongcaoresearch.com |
Dr. Yuhong Cao received her B.S. in chemistry from Linfield College, OR, USA (2011). She conduct graduate work on the development of a nondestructive nanostraw system for longitudinal living cell sampling with Prof. Nicholas Melosh at the Stanford University, CA, USA and got her Ph.D in materials science and engineering (2018). She pursued her postdoctoral training on T cell engineering by applying CRISPR-Cas technology with Prof. Peidong Yang (Fellow of National Academy of Sciences, USA) in partnership with Prof. Jennifer Doudna at the University of California, Berkeley, CA, USA and then returned to Stanford University for her second postdoctoral training with Prof. Steven Chu. She returned to Beijing, China where she joined the National Center for Nanoscience and Technology, CAS as a professor and principal investigator.
Research Interests
The principal research area of Prof. CAO's laboratory revolves around the exploration of topics pertaining to RNA molecules, with a strong emphasis on their potential practical applications. Our endeavors encompass the development of advanced systems for RNA molecule sequence design, the refinement of RNA production processes, the innovation of novel RNA delivery systems, and the investigation of downstream applications for RNA.
Selected publication (full list via Google Scholar)
1. Ziwei Zhang#, Weiyu Li#, Dengwang Luo, Xiushuang Yuan, Li Yu, Yuhong Cao*,
Mitigating cellular dysfunction through contaminant reduction in synthetic circRNA for high-efficiency
mRNA-based cell reprogramming, Advanced Science, 2025, 2416629, 10.1002/advs.202416629.
2. Zhujiang Liu#, Jingkun Zhang#, Yao Cai, Hang Wang, Mingjie Luo, Jiayang Li, Hong Yu, Xiangbing Meng*,
Yuhong Cao*, Improving seed shattering resistance in wild O. alta rice with mesoporous silica
nanoparticle delivery systems, Nano Letters, https://doi.org/10.1021/acs.nanolett.4c02297.
3. Yao Cai, Zhujiang Liu*, Huang Wang, Huan Meng, Yuhong Cao*, Mesoporous silica nanoparticles mediate
siRNA delivery for long-term multi-gene silencing in intact plants, Advanced Science, 2024, 11, 2301358,
4. Yiwen Liao, Dawei Xu, Yuhong Cao*, Yongguan Zhu, Advancing sustainable agriculture: enhancing crop
nutrition with next-generation nanotech-based fertilizers, Nano Research, 2023,
https://doi.org/10.1007/s12274-023-6284-8.
5. Xiushuang Yuan#, Zhanfeng Wu#, Jing Guo, Tianyao Li, Qinghao Cao, Xiangyu Ren, Han Fang, Dawei Xu*,
Yuhong Cao*, Natural wood-derived macroporous cellulose for highly efficient and ultrafast elimination
of double-stranded RNA from in vitro-transcribed mRNA, Advanced Materials, 2023,
https://doi.org/10.1002/adma.202303321.
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