Motao Zhu
| Title： |
Professor |
| E-mail： |
zhumt(AT)nanoctr.cn |
| Affiliation： |
National Center for Nanoscience and Technology (NCNST）
No.11 Beiyitiao Zhongguancun,
100190 Beijing,
P. R. China |
| Group Webpage： |
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Education and Professional Experience:
EDUCATION:
2000.09-2004.07 B.S., Pharmaceutical Science, Peking University, Beijing, China
2004.09-2009.07 Ph.D., Bioinorganic Chemistry, Institute of High Energy Physics, Chinese Academy of Sciences (CAS)
POST-GRADUATE TRAINING:
2017.02-2017.11 Postdoctoral Fellow, Immunology, Rong-Fu Wang, Center for Inflammation and Epigenetics, Houston Methodist Research Institute
ACADEMIC APPOINTMENTS:
2009.09-2013.01 Assistant Professor CAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology
2013.01-2017.01 Associate Professor CAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology
2017.11-2019.10 Research Associate Center for Inflammation and Epigenetics, Houston Methodist Research Institute
2019.11-2021.02
Assistant Professor Department of Medicine, Keck School of Medicine, University of Southern California
1. Guangtong Deng, Chaoran Li, Lang Chen, Changsheng Xing, Chuntang Fu, Chen Qian, Xin Liu, Helen Y. Wang, Motao Zhu*, Rong-Fu Wang*. BECN2 (beclin 2) Negatively Regulates Inflammasome Sensors Through ATG9A-Dependent but ATG16L1- and LC3-Independent Non-Canonical Autophagy. Autophagy 2021. in press
2. Motao Zhu, Libo Du, Ruifang Zhao, Helen Y. Wang, Yuliang Zhao, Guangjun Nie*, Rong-Fu Wang*. Cell-Penetrating Nanoparticles Activate the Inflammasome to Enhance Antibody Production by Targeting Microtubule-Associated Protein 1-Light Chain 3 for Degradation. ACS Nano 2020, 14, 3, 3703-3717.
3. Motao Zhu, Guangtong Deng, Peng Tan, Cuiping Guan, Chongming Jiang, Yinlong Zhang, Bingnan Yin, Changsheng Xing, Bo Ning, Kaifu Chen, Yuliang Zhao, Helen Y. Wang, Beth Levine, Guangjun Nie*, Rong-Fu Wang*. Beclin 2 negatively regulates innate immune signaling and tumor development through non-canonical autophagy. J. Clin. Invest. 2020,130(10):5349-5369.
4. Motao Zhu, Guangtong Deng, Changsheng Xing, Guangjun Nie, Rong-Fu Wang. BECN2 (beclin 2)-mediated non-canonical autophagy in innate immune signaling and tumor development. Autophagy 2020;16(12):2310-2312.
5. Motao Zhu, Xilai Ding, Ruifang Zhao, Xuewu Liu, Haifa Shen, Chunmei Cai, Mauro Ferrari, Helen Y. Wang, Rongfu Wang*. Co-delivery of tumor antigen and dual toll-like receptor ligands into dendritic cell by silicon microparticle enables efficient immunotherapy against melanoma. J. Control. Release. 2018, 272, 72-82.
6. Motao Zhu*, Rongfu Wang, Guangjun Nie. Applications of nanomaterials as vaccine adjuvants. Hum. Vaccin. Immunother. 2014, 10(9):2761-74.
7. Motao Zhu, Guangjun Nie, Andre Nel*, Yuliang Zhao*. Physicochemical Properties Determine Nanomaterial Cellular Uptake, Transport, and Fate. Acc. Chem. Res. 2013, 46(3), 622-631.
8. Motao Zhu, Yiye Li, Jian Shi, Weiyue Feng, Guangjun Nie*, and Yuliang Zhao*. Exosomes as extrapulmonary signaling conveyors for nanoparticle-induced systemic immune activation. Small 2012, 8(3), 404-412 Cover picture.
9. Motao Zhu, Xin Tian, Xiao Song, Yanhua Tian, Yuliang Zhao, Guangjun Nie*. Nanoparticle-induced exosomes target antigen-presenting cells to initiate Th1-type immune activation. Small 2012, 8(18), 2841-2848.
10. Xin Tian1, Motao Zhu1, Yanhua Tian, Ramm Grant, Yuliang Zhao*, Guangjun Nie*. A membrane vesicle-based dual vaccine against melanoma and Lewis lung carcinoma. Biomaterials 2012, 33(26), 6147-54
