Huan Meng
| Title： |
Professor |
| E-mail： |
mengh(AT)nanoctr.cn |
| Affiliation： |
National Center for Nanoscience and Technology (NCNST）
No.11 Beiyitiao Zhongguancun,
100190 Beijing,
P. R. China |
| Group Webpage： |
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Education and Professional Experience:
Dr. Meng received his bachelor’s degree in Pharmaceutical Science from Peking University and his Ph.D. in Bio-inorganic Chemistry from Chinese Academy of Sciences (CAS). After postdoctoral training at David Geffen School of Medicine at UCLA, he joined the faculty in the Department of Medicine as an Assistant Professor. From 2013 to 2021, Dr. Meng held faculty membership in the Jonsson Comprehensive Cancer Center (JCCC), California NanoSystems Institute (CNSI) and Center for Duchenne Muscular Dystrophy (CDMD). In 2020, Dr. Meng was promoted as an Associate Professor in the Department of Medicine at UCLA. In 2021, he became a Full Professor in the National Center for Nanoscience and Technology, CAS.
1. X Liu, J Jiang, Y Liao, I Tang, E Zheng, W Qiu, Mw Lin, X Wang, Y Ji, K Mei, Q Liu, C Hyun Chang, Z A. Wainberg, AE. Nel, H Meng, Combination Chemo-Immunotherapy for Pancreatic Cancer Using the Immunogenic Effects of an Irinotecan Silicasome Nanocarrier plus Anti-PD-1, Advanced Science, 2021, 8, 2002147.
2. X Liu, J Jiang, C Chan, Y Liao, J J. Lodico, I Tang, E Zheng, W Qiu, M Lin, X Wang, Y Ji, K Mei, A E. Nel and H Meng, Development of facile and versatile platinum drug delivering silicasome nanocarriers for efficient pancreatic cancer chemo-immunotherapy, Small, 2021, 17, 2005993.
3. Y Ji, X Liu, J Li, X Xie, M Huang, J Jiang, YP Liao, T Donahue, H Meng, Use of Ratiometrically Designed Nanocarrier Targeting CDK4/6 And Autophagy Pathways for Effective Pancreatic Cancer Treatment, Nature Communications, 2020, 11, 4249.
4. X Liu, I Tang, Z A. Wainberg and H Meng, Safety Considerations of Cancer Nanomedicine – A Key Step Towards Translation, Small, 2020, 2000673.
5. KC Mei, YP Liao, J Jiang, M Chiang, M Khazaieli, X Liu, X Wang, Q Liu, CH Chang, X Zhang, J Li, Y Ji, B Melano, D Telesca, T Xia, H Meng, AE Nel, Liposomal Delivery of Mitoxantrone and a Cholesteryl Indoximod Prodrug Provides Effective Chemo-Immunotherapy in Multiple Solid Tumors, ACS Nano, 2020, 14, 13343-13366.
6. X Liu, J Jiang, H Meng, Transcytosis – An effective targeting strategy that is complementary to “EPR effect” for pancreatic cancer nano drug delivery, Theranostics, doi:10.7150/thno.38587; 2019, 9: 8018-8025.
7. X Liu, J Jiang, R Chan, Y Ji, J Lu, YP Liao, M Okene, J Lin, P Lin, CH Chang, X Wang, I Tang, E Zheng, W Qiu, ZA. Wainberg, AE. Nel, and H Meng, Improved Efficacy and Reduced Toxicity Using a Custom-Designed Irinotecan-Delivering Silicasome for Orthotopic Colon Cancer, ACS Nano, 2019, 13, 38-53.
8. Y Ji, X Liu, M Huang, J Jiang, YP Liao, Q Liu, CH Chang, H Liao, J Lu, X Wang, SM Spencer, H Meng, Development of self-assembled multi-arm polyrotaxanes nanocarriers for systemic plasmid delivery in vivo. Biomaterials, 2019, 192, 416-428.
9. M R. Emami, C S. Young, Y Ji, X Liu, AD. Pyle, H Meng, and M J. Spencer, Polyrotaxane nanocarriers can deliver CRISPR/Cas9 plasmid to dystrophic muscle cells to successfully edit the DMD gene, Advanced Therapeutics, 2019, 2, 1900061.
10. X Liu, P Lin, I Perrett, J Lin, Y Liao, CH Chang, J Jiang, N Wu, T Donahue, Z Wainberg, A Nel, and H Meng, Tumor-Penetrating Peptide Enhances Transcytosis of Silicasome-based Chemotherapy for Pancreatic Cancer, The Journal of Clinical Investigation, 2017, 127, 2007-2018.
11. X Liu, A Situ, Y Kang, K Villabroza, Y Liao, C H Chang, T Donahue, A E Nel, and H Meng, Irinotecan Delivery by Lipid-Coated Mesoporous Silica Nanoparticles Show Improved Efficacy and Safety over Liposomes for Pancreatic Cancer, ACS Nano, 2016, 10, 2702-2715.
12. H Meng, W Leong, K W. Leong, C Chen, YL Zhao, Walking the line: The fate of nanomaterials at biological barriers, Biomaterials, 2018, 174, 41-53 (review paper).
13. H Meng, A Nel, Use of Nano Engineered Approaches to Overcome the Stromal Barrier in Pancreas Cancer, Advanced Drug Delivery Review, 2018, 130, 50-57 (review paper).
