In 2017, Yaoxin LIN obtained his Ph.D. degree from the University of Chinese Academy of Sciences at the National Center for Nanoscience and Technology, primarily engaged in research on "in vivo self-assembled" nanoprobes and the design, construction, and application of intelligent nanodrugs based on autophagy regulation. Subsequently, he conducted postdoctoral research on mRNA vaccines/drugs at Harvard Medical School and Brigham and Women's Hospital.

Research Interests

1. Design of mRNA vaccine carrier materials and screening/optimization of nanoformulations;

2. Tumor microenvironment-responsive intelligent nanodrugs and tumor immunoregulation therapy;

3. Development of intelligent nanodrugs or theranostic strategies based on autophagy regulation.

Selected Publications (full list via Google Scholar)

1. Lin, Y.-X.#; Wang Y.#; Ding, J.; Jiang, A.; Wang, J.; Yu, M.; Blake, S.; Bieberich, C.; Farokhzad, O.; Mei, L; Wang, H.; Shi, J. Tumor Suppressor Reactivation by mRNA Nanoparticles Induces Anti-Tumor Immunity and Improves Immune Checkpoint Blockade Therapy. Sci. Transl. Med. (2021, 13, eaba97). 

2. Lin, Y.-X.#; Wang Y.#; An, H.-W.; Wang, L.; Shi, J.; Mei, L. and Wang, H. Peptide-based Autophagic Gene and Cisplatin Co-delivery Systems Enable Improve Chemotherapy Resistance. Nano Lett. 2019, 19, 2968-2978.  

3. Wang Y. #; Lin, Y.-X.#; Wang, J.; Qiao, S.; Liu, Y.; Dong, W.; Wang, J.; An, H.; Yang, C.; Mamti, M.; Wang, L.; Hang, B.; and Wang, H. In Situ Manipulation of Dendritic Cells by an Autophagy-Regulative Nanoactivator Enables Effective Cancer Immunotherapy. ACS Nano 2019, 137, 7568-7577.   

4. Luo, Q.#; Lin, Y.-X.#; Yang, P.-P.#; Wang, Y.; Qi, G.; Qiao, Z.-Y.; Li, B.; Zhang, K.; Zhang, J.; Wang, L.; Wang, H. A Self-destructive Nanosweeper that Captures and Clears Amyloid β-peptides. Nat. Commun. 2018, 9, 1802.  

5. Lin, Y.-X.#; Hu, X.-F.#; Zhao, Y.#; Gao, Y.-J.; Yang, C.; Qiao, S.-L.; Wang, Y.; Yang, P.-P.; Li, L.-L.; Xie, J.-B.; Zhu, S.-Q.; Wu, X.C.; Wang L. and Wang H. Photothermal Ring Integrated Intraocular Lens for High-Efficient Eye Disease Treatment. Adv. Mater. 2017, 29, 1701617.  

6. Lin, Y.-X.; Qiao, S.-L.; Wang, Y.; Zhang, R.-X.; An, H.-W.; Ma, Y.; Rajapaksha, R. P. Y. J.; Qiao, Z.-Y.; Wang, L.; Wang, H. An in situ Intracellular Self-Assembly Strategy for Quantitatively and Temporally Monitoring Autophagy. ACS Nano 2017, 11, 1826-1839.  

7. Qiao, Z.-Y.#; Lin, Y.-X.#; Lai, W.-J.; Hou, C.-Y.; Wang, Y.; Qiao, S.-L.; Zhang, D.; Fang, Q.-J.; Wang, H. A General Strategy for Facile Synthesis and in situ Screening of Self-Assembled Polymer-Peptide Nanomaterials. Adv. Mater. 2016, 28, 1859-1867.  

8. Wang, Y.#; Lin, Y.-X.#; Qiao, Z.-Y.; An, H.-W.; Qiao, S.-L.; Wang, L.; Rajapaksha, R. P. Y. J.; Wang, H. Self-Assembled Autophagy-Inducing Polymeric Nanoparticles for Breast Cancer Interference in-vivo. Adv. Mater. 2015, 27, 2627-2634.  

9. Lin, Y.-X.; Wang Y.; Qiao, S.-L.; An, H.-W.; Wang, L. and Wang, H. "In vivo self-assembled" nanoprobes for optimizing autophagy-mediated chemotherapy. Biomaterials 2017, 141, 199-209.  

10. Lin, Y.-X.; Wang, Y; and Wang H. Recent Advances in Nanotechnology for Autophagy Detection. Small 2017, 13, 1700996.  

11. Lin, Y.-X.; Wang, Y.; Qiao, S.-L.; An, H.-W.; Zhang, R.-X.; Qiao, Z.-Y.; Rajapaksha, R. P. Y. J.; Wang, L.; Wang, H. pH-Sensitive Polymeric Nanoparticles Modulate Autophagic Effect via Lysosome Impairment. Small 2016, 12, 2921-2931.  

12. Lin, Y.-X.#; Wang, Y.#; Blake, S.; Yu, M.; Mei, L.; Wang, H.; Shi, J. RNA Nanotechnology-Mediated Cancer Immunotherapy. Theranostics 2020, 10 (1), 281.  

13. Lin, Y.-X.; Gao, Y.-J.; Wang, Y.; Qiao, Z.-Y.; Fan, G.; Qiao, S.-L.; Zhang, R.-X.; Wang, L.; Wang, H. pH-Sensitive Polymeric Nanoparticles with Gold(I) Compound Payloads Synergistically Induce Cancer Cell Death through Modulation of Autophagy. Mol. Pharmaceutics 2015, 12, 2869-2878.  

14. Qiao Z.-Y.#; Lai W.-J.#; Lin Y.-X.#; Li D.; Nan X.; Wang Y.; Wang H.; and Fang Q. Polymer-KLAK Peptide Conjugates Induce Cancer Cell Death through Synergistic Effects of Mitochondria Damage and Autophagy Blockage. Bioconjugate Chem. 2017, 28, 1709–1721.