National Center for Nanoscience and Technology, China

Faculty

Yanlian Yang

Title：	Professor
E-mail：	yangyl(AT)nanoctr.cn
Affiliation：	National Center for Nanoscience and Technology (NCNST) No.11 Beiyitiao Zhongguancun, 100190 Beijing, P. R. China
Group Webpage：

Education and Professional Experience:

Yang Yanlian, PhD, Professor of the National Center for Nanoscience and Technology, Deputy Director of the CAS Key Laboratory of standardization and Measurement for Nanotechnology. She received B.S. and M.S. degrees in Chemistry from Shandong University in 1996 and 1999, respectively. In 2002, she obtained PhD degree in Physical Chemistry from Peking University, and then worked as a postdoctoral researcher in Peking University from 2002 to 2004. Since 2004, she joined National Center for Nanoscience and Technology (NCNST). She was a visiting scholar at the Center for Biomedical Engineering, Massachusetts Institute of Technology from 2007 to 2008. She currently is a Professor in NCNST.

She has been PIs of a number of National Key Research Projects. She has published nearly 200 papers in high-profile peer reviewed journals such as Chem. Soc. Rev. Nat. Commun., Natl. Acad. Sci. USA, J. Am. Chem. Soc., Angew. Chem. Int. Ed., Nano Today, Nano Lett., and ACS Nano with citation ~4,000 times. H index 35.

Research Interests:

1. Huiwen Du, Xiaoyu Hu, Hongyang Duan, Lanlan Yu, Fuyang Qu, Qunxing Huang, Wangshu Zheng, Hanyi Xie, Jiaxi Peng, Rui Tuo, Dan Yu, Yuchen Lin, Wenzhe Li, Yongfang Zheng, Xiaocui Fang, Yimin Zou, Huayi Wang, Mengting Wang, Paul S. Weiss*, Yanlian Yang*, Chen Wang*, “Principles of Inter-Amino-Acid Recognition Revealed by Binding Energies between Homogeneous Oligopeptides” ACS Central Science, 2019, 5(1), 97-108 DOI: 10.1021/acscentsci.8b00723 (Cover Story).

2. Yongfang Zheng, Lanlan Yu, Yimin Zou, Yanlian Yang*, Chen Wang* “Steric Dependence of Chirality Effect in Surface-Mediated Peptide Assemblies Identified with Scanning Tunneling Microscopy”, Nano Letters, 2019, 19(8), 5403-5409, DOI: 10.1021/acs.nanolett.9b0190412.

3. Wenzhe Li, Huayi Wang, Zijian Zhao, Houqian Gao, Changliang Liu, Ling Zhu,*Chen Wang,* and Yanlian Yang* “Emerging Nanotechnologies for Liquid Biopsy: The Detection of Circulating Tumor Cells and Extracellular Vesicles”, Advanced Materials, 2018,1805344; DOI: 10.1002/adma.201805344 (Cover Story).

4. Yumin Chen, Ke Deng*, Shengbin Lei, Rong Yang, Tong Li , Yuantong Gu, Yanlian Yang*, Xiaohui Qiu* ,Chen Wang*, “Single-molecule insights into surface-mediated homochirality in hierarchical peptide assembly”, Nature Communications, 2018, 9(1): 2711;DOI: 10.1038/s41467-018-05218-0.

5. Wenzhe Li, Bin Shao, Changliang Liu, Huayi Wang, Wangshu Zheng, Weiyao Kong, Xiaoran Liu, Guobin Xu, Chen Wang, Huiping Li,* Ling Zhu,* and Yanlian Yang*, “Noninvasive Diagnosis and Molecular Phenotyping of Breast Cancer through Microbead-Assisted Flow Cytometry Detection of Tumor-Derived Extracellular Vesicles” Small Methods, 2018, 2(11), 1800122; DOI: 10.1002/smtd.201800122 (Cover Story).

6. Ling Zhu, Zijian Zhao, Peng Cheng, Zhaohui He, Zhiqiang Cheng, Jiaxi Peng, Huayi Wang, Chen Wang,* Yanlian Yang,* and Zhiyuan Hu*, “Antibody-Mimetic Peptoid Nanosheet for Label-Free Serum-Based Diagnosis of Alzheimer’s Disease”, Adv. Mater. 2017, 29, doi.org/10.1002/adma.201700057.

7. Niu, Lin1; Liu, Lei1; Xi, Wenhui1; (Equal contribution) Li, Qiang; Han, Qiusen; Yu, Yue; Huang, Qunxing; Qu, Fuyang; Xu, Meng; Li, Yibao; Du, Huiwen; Yang, Rong; Cramer, Jacob; Gothelf, Kurt; Dong, Mingdong; Besenbacher, Flemming; Zeng, Qingdao; Wang, Chen*; Wei, Guanghong*; Yang, Yanlian*, “Synergistic inhibitory effect of Peptide-Organic Co-assemblies on Amyloid Aggregation”, ACS Nano, 2016, 10 (4), pp 4143–4153.

8. Lei Liu, Lin Niu, (Equal contribution) Meng Xu, Qiusen Han, Hongyang Duan, Mingdong Dong, Flemming Besenbacher, Chen Wang*, Yanlian Yang*, “Molecular tethering effect of C-terminus of amyloid peptide A42”, ACS Nano, 2014, 8(9), 9503-9510.

9. Shelley A. Claridge, Jeffrey J. Schwartz, Miles A. Silverman, John C. Thomas, Yanlian Yang,* Chen Wang,* and Paul S. Weiss*, “Differentiating Amino Acid Residues and Side Chain Orientations in Peptides Using Scanning Tunneling Microscopy” J. Am. Chem. Soc. 2013,135(49), 18528–18535.

10. Xiaobo Mao1, Yuanyuan Guo1, Yin Luo1, (Equal contribution) Lin Niu, Lei Liu, Xiaojing Ma, Huibin Wang, Yanlian Yang*, Guanghong Wei*, Chen Wang*, “Sequence Effects on Peptide Assembly Characteristics Observed by Using Scanning Tunneling Microscopy” J. Am. Chem. Soc. 2013, 135 (6), 2181–2187.

11. Min Zhang, Xiaobo Mao, Yue Yu, Chenxuan Wang, Xiaobo Mao, Yanlian Yang,* Chen Wang* “Nanomaterials for reducing amyloid cytotoxicity”, Adv. Mater.,2013, DOI: 10.1002/adma.201301210.

12. Min Zhang1, Xiaobo Mao1, (Equal contribution) Chenxuan Wang, Wenfeng Zeng, Chunling Zhang, Zhongjun Li, Ying Fang, Yanlian Yang,* Wei Liang*, Chen Wang*, “The Effect of Graphene oxide on Conformation Change, Aggregation and Cytotoxicity of HIV-1 Regulatory Protein (Vpr)”, Biomaterials, 2013, 34(4), 1383-1390.

13. Xiaobo Mao, Chenxuan Wang, Xingkui Wu, Xiaojing Ma, Lei Liu, Lan Zhang, Lin Niu, Yuanyuan Guo, Denghua Li, Yanlian Yang*, Chen Wang*, “Beta structure motifs of islet amyloid polypeptides identified through surface-mediated assemblies” Proc. Natl. Acad. Sci. USA. 2011, 108(49), 19605-19610.

14. Lei Liu#, Lan Zhang# (Co-first authors), Lin Niu, Meng Xu, Xiaobo Mao, Yanlian Yang*, Chen Wang*, “Observation of Reduced Cytotoxicity of Aggregated Amyloidogenic Peptides with Chaperone-like Molecules” ACS Nano, 2011, 5(7), 6001-6007.

15. Yanlian Yang, Chen Wang*, Hierarchical construction of self-assembled low-dimensional molecular architectures observed by using scanning tunneling microscopy, Chem. Soc. Rev., 2009, 38, 2576-2589.

16. Lei Liu, Lan Zhang, Xiaobo Mao, Lin Niu, Yanlian Yang,* and Chen Wang* “Chaperon-Mediated Single Molecular Approach Toward Modulating Ab Peptide Aggregation” Nano Lett., 2009, 9(12), 4066-4072.

17. Yanlian Yang, Ulung Khoe, Xiumei Wang, Akihiro Horii, Hidenori Yokoi and Shuguang Zhang* “Designer Self-assembling Peptide Nanomaterials”, Nano Today, 2009, 4, 193-210.

18. Yanlian Yang, Qilin Chan, Xiaojing Ma, Yongtao Shen, Ke Deng, Xizeng Feng*, Chen Wang*, Electrical Conformational Bistability of Dimesogen Molecules with a Molecular Chord Structure”, Angew. Chem. Int. Ed., 2006, 45, 6889-6893.